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2 |
Dehydroepiandrosterone (DHEA) for systemic lupus erythematosus
This summary of a Cochrane review presents what we know from research about the effect of dehydroepiandrosterone (DHEA) for lupus. The review shows that:
DHEA probably leads to little or no difference in disease activity in people with mild to moderate disease, but probably slightly improves overall well-being. These results are based on moderate quality evidence.
DHEA may improve disease activity in people with severe or active lupus, but this result is based on low quality evidence so there is not enough evidence to be certain.
It is not known whether DHEA reduces the damage that lupus causes to organs as damage was not measured in the studies.
Possible side effects may include acne, excessive hair growth, and menstrual changes. But we often do not have precise information about side effects and complications.
It is not known whether DHEA causes long term side effects such as heart problems or cancer. This is because there were not many people in the studies and the longest study was only 1 year long.
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152 |
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4 |
Systemic Lupus Erythematosus: Emerging Concepts: Part 1: Renal, Neuropsychiatric, Cardiovascular, Pulmonary, and Hematologic Disease
Purpose: To review advances and controversies in the diagnosis and management of systemic lupus erythematosus with visceral involvement (renal, neuropsychiatric, cardiopulmonary, and hematologic disease).
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92 |
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5 |
Systemic Lupus Erythematosus: Emerging Concepts: Part 2: Dermatologic and Joint Disease, the Antiphospholipid Antibody Syndrome, Pregnancy and Hormonal Therapy, Morbidity and Mortality, and Pathogenesis
Purpose: To review 1) advances in the pathogenesis, diagnosis, and management of dermatologic and joint disease and the antiphospholipid antibody syndrome in patients with systemic lupus erythematosus; 2) controversies related to pregnancy and hormonal therapy and to morbidity and mortality in these patients; and 3) current views on the pathogenesis of systemic lupus erythematosus.
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105 |
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7 |
Lupus Research Update
Welcome to the Alliance for Lupus Research's (ALR's) Lupus Research Update (LRU).
We are proud to present you with the latest breaking news from the lupus research community. In every LRU, you'll learn about everything from the most technical advances in lupus science and ALR-funded investigator profiles, to the latest Walk with Us to Cure Lupus and grassroots advocacy program news. We are also proud to introduce a new "Face of Lupus" in each quarterly newsletter.
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92 |
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8 |
Systemic Lupus Erythematosus - Review article 2008
To the clinician, systemic lupus erythematosus is important because it is a potentially fatal disease that is easily confused with many other disorders. To the immunologist, lupus is intriguing because all the key components of the immune system are involved in the underlying mechanisms of the disease. This review describes these mechanisms and shows how knowledge of the pathogenesis of lupus facilitates its treatment.
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97 |
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9 |
Unraveling the Genetic Predisposition to Systemic Lupus Erythematosus
A collection of studies and commentary focus on the identification of genetic defects associated with risk for SLE.
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122 |
Nettlenker 